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Original Research Article | OPEN ACCESS

Phytochemical analysis and hepatoprotective activity of Raphanus sativus var. sativus in Sprague-Dawley rats

Heshu Sulaiman Rahman1,2 , Kashan Alaalddin Bayz3, Ridha Hassan Hussein4, Azad Ismael Abdalla3, Hemn Hassan Othman5, Kawa Mohammad Amin1, Rasedee Abdullah6

1College of Medicine, Sulaimani New, University of Sulaimani; 2College of Health Sciences, Komar University of Science and Technology, Sarchinar District; 3College of Agriculture, University of Sulaimani, Bakrajo District; 4College of Science, Tasluja, Street 1, Zone 501; 5College of Pharmacy, Sulaimani New, University of Sulaimani, Sulaymaniyah, Republic of Iraq; 6Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia.

For correspondence:-  Heshu Rahman   Email: heshu.rhaman@univsul.edu.iq   Tel:+9647726159598

Accepted: 20 July 2020        Published: 31 August 2020

Citation: Rahman HS, Bayz KA, Hussein RH, Abdalla AI, Othman HH, Amin KM, et al. Phytochemical analysis and hepatoprotective activity of Raphanus sativus var. sativus in Sprague-Dawley rats. Trop J Pharm Res 2020; 19(8):1745-1752 doi: 10.4314/tjpr.v19i8.25

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the phenolic and flavonoid contents of R. sativus rhizome ethanol extract and the hepatoprotective effect of the extract in rats.
Methods: Folin–Ciocalteau and aluminum chloride colorimetric tests were used to determine the contents of phenols and flavonoids in the R. sativus extract. Male Sprague-Dawley rats induced with CCl4 to develop hepatotoxicity were treated orally with R. sativus extract for 4 weeks. The antioxidant and anti-inflammatory effects of the extract on the liver were determined by evaluating the concentration of oxidative analytes, serum liver enzymes and lipids, and hepatic histopathology and cytochrome P450 2E1 expression.
Results: R. sativus extract significantly (p < 0.05) reduced the hepatotoxic effect of CCl4 via its antioxidant activities and protection of liver tissues from oxidative damage.
Conclusion: The hepatoprotective effects of R. sativus rhizome ethanol extract are attributed to its high phenolic and flavonoid contents.

Keywords: R. savitus rhizome, Phenols, Flavonoid contents, antioxidant, Hepatoprotective

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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